Alexander A. Avdoshin

Ph. D. stu­dent, Depart­ment of Chem­istry, Lobachevsky State Uni­ver­si­ty of Nizh­ny Nov­gorod

Posi­tion:

Junior Researcher of Mol­e­c­u­lar Mod­el­ing and Chemoin­for­mat­ics Lab­o­ra­to­ry

E-mail: avdoshinaa95@gmail.com

Sci­en­tif­ic inter­ests:

• Mol­e­c­u­lar dynam­ics study for tar­get deliv­ery sys­tems for RNA and pro­tein drugs based on Chi­tosan and its deriv­a­tives.
• Force Fields.
• Neur­al net­work poten­tial for met­al clus­ter.

Aca­d­e­m­ic Edu­ca­tion:

• 2013 – 2017: Depart­ment of Chem­istry, Lobachevsky State Uni­ver­si­ty of Nizh­ny Nov­gorod (Bach­e­lor of Sci­ence)
• 2017 – 2019: Depart­ment of Chem­istry, Lobachevsky State Uni­ver­si­ty of Nizh­ny Nov­gorod (Mas­ter of Sci­ence)
• 2019 to present: Depart­ment of Chem­istry, Lobachevsky State Uni­ver­si­ty of Nizh­ny Nov­gorod (Ph. D. stu­dent)

 Work Expe­ri­ence:

• 2021 – Present: Junior Researcher, the Lab­o­ra­to­ry of Mol­e­c­u­lar Mod­el­ing and Chemoin­for­mat­ics, Lobachevsky State Uni­ver­si­ty of Nizh­ny Nov­gorod.
• 2019 Junior Phd Researcher, Bre­men Uni­ver­si­ty, HMI group
• 2021 Junior Phd Researcher, Bre­men Uni­ver­si­ty, HMI group

Lan­guages:

Russ­ian (native), Eng­lish (flu­ent)

Key Ideas:

MicroR­NA is con­sid­ered today as a prospec­tive phar­ma­co­log­i­cal agent for the devel­op­ment of nov­el high-tech­no­log­i­cal med­i­cines. Insulin is wild­ly used in med­i­cine as a drug for dia­betes. These two drugs we took as exam­ples of dif­fer­ent forms of med­i­cine. In order to keep their active form in the aggres­sive bio­log­i­cal envi­ron­ment, they usu­al­ly needs pro­tec­tive drug deliv­ery car­ri­ers. Chi­tosan is one of the most poten­tial mate­ri­als for such car­ri­ers owing to many use­ful prop­er­ties such as mucoad­he­sion, ease of mod­i­fi­ca­tion, low cost and bio­com­pat­i­bil­i­ty.

We inves­ti­gate the prob­lem with clas­si­cal mol­e­c­u­lar dynam­ics sim­u­la­tions of chi­tosan poly­mer — miR­NA and chi­tosan — Insulin com­plex­es. For chi­tosan, the degree of pro­to­na­tion and acety­la­tion show a clear influ­ence on the for­ma­tion of the com­plex­es.

Select­ed pub­li­ca­tions:

1. Glazo­va, I., et al., Inter­poly­mer inter­ac­tion in insulin-chi­tosan com­plex­es. Supramol­e­c­u­lar Chem­istry, 2019. 31(6): p. 412–423.
2. Nau­mov, V.S., et al., Struc­tur­al, elec­tron­ic, and ther­mo­dy­nam­ic prop­er­ties of TiO2/organic clus­ters: per­for­mance of DFTB method with dif­fer­ent para­me­ter sets. Inter­na­tion­al Jour­nal of Quan­tum Chem­istry, 2021. 121(2): p. e26427.